U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Other

Class (Stereo):
CHEMICAL (EPIMERIC)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Targets:

Conditions:

4'-demethylepipodophyllotoxin (DMEP) belongs to the class of podophyllotoxin. Podophyllotoxin is a natural product from the roots and rhizomes of Podophyllum species and binds at the colchicine site as a microtubule inhibitor. DMEP is an antimitotic agent which binds to monomeric tubulin, preventing microtubule polymerization. It can reduce the tumor formation and growth in a mouse skin carcinogenesis model. DMEP derivatives exert strong antitumor properties.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
US Previously Marketed
First approved in 1992

Class (Stereo):
CHEMICAL (ABSOLUTE)



Teniposide is an inhibitor of topoisomerase II with anti-cancer activity. The drug was approved by FDA under the name Vumon for the treatment of children with acute lymphoblastic leukemia.